537 research outputs found

    Investigating the impact of unfamiliar speaker accent on auditory comprehension in adults with aphasia

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    Background: In an increasingly multicultural society, all individuals are likely to come into contact with speakers with unfamiliar accents. Recent figures suggest that such accent variation may be particularly apparent within the healthcare workforce. Research on accent variation has demonstrated that an unfamiliar speaker accent can affect listener comprehension, but the impact of speaker accent on the comprehension skills of listeners with neurological impairment has not been widely explored.Aims: To investigate the effect of an unfamiliar accent on the sentence comprehension of individuals with aphasia following stroke.Methods & Procedures: The impact of two different accents (south-east England and Nigerian) on accuracy and response time for 16 individuals with aphasia and 16 healthy control subjects was measured. Participants were presented with a computerized sentence-to-picture matching task and their accuracy and response times were recorded.Outcomes & Results: Results showed that individuals with aphasia made significantly more errors in comprehension of sentences spoken in an unfamiliar accent than in a familiar accent, a finding that was not demonstrated by the control group when outliers were excluded. Individuals with aphasia were slower overall; however, response times did not show significant effects of speaker accent for either group.Conclusions & Implications: The impact of speaker accent should be considered in the rehabilitation of individuals with aphasia following stroke. Clinical implications include the possibility of underestimating an individual's language abilities on assessment, and the potential errors in comprehension that may occur

    Investigating the impact of unfamiliar speaker accent on auditory comprehension in adults with aphasia

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    The UK is a highly multi-cultural society, where all individuals are likely to come into contact with speakers with unfamiliar accents. Recent figures suggest that such accent variation may be particularly apparent within the National Health Service (NHS) workforce. Research on accent variation has demonstrated that an unfamiliar speaker accent can affect listener comprehension, but the impact of speaker accent on the comprehension skills of listeners with neurological impairment has not been widely explored. This study investigated the effect of an unfamiliar accent on the sentence comprehension of individuals with aphasia following stroke. It measured the impact of two different accents (South-East England and Nigerian) on accuracy and response time for 16 individuals with aphasia and 16 control subjects. Participants were presented with a computer-based sentence comprehension task using stimuli from the Comprehensive Aphasia Test (Swinburn, Porter & Howard, 2004), and their accuracy and response times were recorded. Results showed that individuals with aphasia made significantly more errors in comprehension of sentences spoken in an unfamiliar accent than in a familiar accent, a finding that was not demonstrated by the control group when outliers were excluded. Response times did not show significant effects of speaker accent for either group. The findings of this study indicate that the impact of speaker accent should be considered in the rehabilitation of individuals with aphasia following stroke, and a number of possible clinical implications are discussed

    Linear recurrences of order two

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    Remaking the self in John Dunton’s The Life and Errors of John Dunton (1705)

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    © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. John Dunton (1659–1732) is a bookseller and writer best known today as a tireless self-promoter whose I-centred and experimental work contributed to the development of the novel and autobiography in the eighteenth century. This article is the first full-length study of his own autobiographical record, The Life and Errors of John Dunton (1705). Dunton the showman is in plentiful evidence in this text, but he also presents another, more sober and serious-minded version of the self by following accounts of earlier stages of his life with their reformed versions. His coupling of religious-led self-examination with a commitment to literary novelty makes The Life a most unusual form of spiritual autobiography in its early stages. Yet The Life is a composite text in an even more obvious sense than this. For around half-way through the text Dunton abandons his close focus on the self for hundreds of cursory character sketches of his contemporaries, and in doing so swaps spiritual considerations for indirect comments on his own social activities and commercial concerns. This article studies these two main, ostensibly opposed, sections of The Life–its autobiographical and biographical material–and suggests points of contact between them

    The SISO CSPI PDG standard for commercial off-the-shelf simulation package interoperability reference models

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    For many years discrete-event simulation has been used to analyze production and logistics problems in manufactur-ing and defense. Commercial-off-the-shelf Simulation Packages (CSPs), visual interactive modelling environ-ments such as Arena, Anylogic, Flexsim, Simul8, Witness, etc., support the development, experimentation and visua-lization of simulation models. There have been various attempts to create distributed simulations with these CSPs and their tools, some with the High Level Architecture (HLA). These are complex and it is quite difficult to assess how a set of models/CSP are actually interoperating. As the first in a series of standards aimed at standardizing how the HLA is used to support CSP distributed simula-tions, the Simulation Interoperability Standards Organiza-tion’s (SISO) CSP Interoperability Product Development Group (CSPI PDG) has developed and standardized a set of Interoperability Reference Models (IRM) that are in-tended to clearly identify the interoperability capabilities of CSP distributed simulations

    Salvaging Detection of Early-Stage Ovarian Malignancies When CA125 Is Not Informative

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    Background: Ovarian cancer is the deadliest gynecologic cancer, with no recommended screening test to assist with early detection. Cancer antigen 125 (CA125) is a serum biomarker commonly used by clinicians to assess preoperative cancer risk, but it underperforms in premenopausal women, early-stage malignancies, and several histologic subtypes. OVA1 is a multivariate index assay that combines CA125 and four other serum proteins to assess the malignant risk of an adnexal mass. Objective: To evaluate the performance of OVA1 in a cohort of patients with low-risk serum CA125 values. Study Design: We analyzed patient data from previous collections (N = 2305, prevalence = 4.5%) where CA125 levels were at or below 67 units/milliliter (U/mL) for pre-menopausal women and 35 U/mL for post-menopausal women. We compare the performance of OVA1 to CA125 in classifying the risk of malignancy in this cohort, including sensitivity, specificity, positive and negative predictive values. Results: The overall sensitivity of OVA1 in patients with a low-risk serum CA125 was 59% with a false-positive rate of 30%. OVA1 detected over 50% of ovarian malignancies in premenopausal women despite a low-risk serum CA125. OVA1 also correctly identified 63% of early-stage cancers missed by CA125. The most common epithelial ovarian cancer subtypes in the study population were mucinous (25%) and serous (23%) carcinomas. Despite a low-risk CA125, OVA1 successfully detected 83% of serous, 58% of mucinous, and 50% of clear cell ovarian cancers. Conclusions: As a standalone test, CA125 misses a significant number of ovarian malignancies that can be detected by OVA1. This is particularly important for premenopausal women and early-stage cancers, which have a much better long-term survival than late-stage malignancies. Using OVA1 in the setting of a normal serum CA125 can help identify at-risk ovarian tumors for referral to a gynecologic oncologist, potentially improving overall survival
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